Pair Name	Sulforaphane, Metformin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Down-regulation	Expression	CD44	hsa960
	Down-regulation	Expression	CTNNB1	hsa1499
	Down-regulation	Expression	ERBB2	hsa2064
	Down-regulation	Expression	SRC	hsa6714
	Down-regulation	Expression	WNT1	hsa7471
In Vitro Model	BT-474	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0179
Result	Our data indicate that SLFN and MTFN can reduce cancer cell viability via both collaborative and differential effects and suggest that MTFN increases SLFN effectiveness by targeting common molecules/pathways downstream of HER2 and key for CSC signaling.